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    Tacrolimus is an immunosuppressive drug widely used in individuals with an organ transplant. In addition to this, it has multiple uses in human medicine and veterinary medicines. THYKN Pharma Outsourcing works tirelessly to provide elite quality tacrolimus API.

    COMMON USES OF TACROLIMUS:

    • To prevent organ transplant rejection.
    • To cure post-transplant uveitis.
    • To treat eczema and dermatitis.
    • To remedy severe episodes of Minimal Change Disease and vitiligo.
    • In cats and dogs, it is used to treat dry eye syndrome.

    STORAGE OF TACROLIMUS:

    Tacrolimus, in its monohydrate form, requires cold temperatures for adequate storage. A dry and well-ventilated storage place is also mandatory. The optimal temperature for the repository is -20℃.

    Category:

    Description

    Tacrolimus is an efficient immune system suppressant drug. Chemically, it belongs to the macrolide lactone group of compounds. A member of the WHO’s list of essential medicines, tacrolimus is utilized to prevent organ transplant rejection. It is used after nearly all kinds of allogeneic transplants, such as liver, cornea, heart, etc.

    BASIC INFO.:

    • Model number:
    • CAS number: 104987-11-3
    • Name: Tacrolimus.
    • Trademark:
    • Specifications: An immunosuppressive drug used to prevent transplant rejection and other immune system-related diseases.
    • Mf:
    • MOQ:
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    • Original:

    PRODUCT SPECIFICATIONS:

    • Treatment and Function: It suppresses the immune system and prevents organ rejection after the transplant.
    • Physical Form: White Powder.
    • Medicine Type: Human and Veterinary Drug.
    • Ingredients: Tacrolimus API.
    • Recommended for: People who underwent any organ transplant. Cats or dogs suffering from dry eye syndrome can use it.
    • Storage:  Store this drug in a dry and cold environment as cold as -20℃.

    USES:

    After the transplant, the risk of rejection is very high. The use of tacrolimus can prevent rejection. No matter what kind of transplant has happened, this drug is one of the best to avoid rejection. It can be used to manage acute exacerbations of uveitis, minimal change disease, and vitiligo. Tacrolimus is also available in topical form to treat eczema, dermatitis, etc.

    In veterinary medicine, dry eye syndrome can be dealt with effectively with tacrolimus.

    CHEMICAL COMPOSITION:

    The molecular formula of tacrolimus is C44H69NO12. IUPAC name for this compound is (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-1,14-dihydroxy-12-[(E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-prop-2-enyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone and is a macrolide lactone.

    PRODUCT APPLICATION:

    Tacrolimus is an inhibitor of calcineurin, an enzyme that can activate T-lymphocytes. T-Lymphocytes are an essential component of the immune system. In addition to this, tacrolimus also inhibits the synthesis of interleukin-2. Both these actions lead to reduced immune response. This reduction in immunity helps prevent transplant organ rejection.

    PHYSICAL AND CHEMICAL PROPERTIES:

    • Melting Point – 126℃
    • Density – 1.2±0.1g/cm3
    • Form – Powder
    • HS Code – 29419090
    • Color – White
    • Molecular Weight – 804.03g/mol
    • Solubility – Insoluble in Water.

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